【学习及工作经历】

• 教育：
  1994-1993:  New York University,博士后；
  1990-1984： 南开大学，硕士，博士；
  1982-1978： 复旦大学，学士；
  
  

•  

• 经历：




• 1999-今:    3044am永利集团化学系，研究员。2001年起，博士生导师;




• 1999-1998:  New York University, 访问教授；




• 1998-1997:  3044am永利集团化学系, 副教授；




• 1994-1996:  Peptosyn Inc. )研究科学家；




• 1993-1990:  天津轻工业化学研究所，高工。

【主讲课程】

• 有机化学（大本基础课,双语,泰山学堂，化基班）；
  有机合成（大本专业课）；
  理论有机化学（硕士生专业基础课）；
  立体化学与手性合成（博士生专业基础课）；

• 药物设计与合成（博士生专业选修课）。
  

【研究领域和兴趣】

•  有机合成：有机合成新反应及新方法。手性合成及功分子合成。天然化合物的全合成及结构修饰;
   药物化学：新药物分子设计、合成及构效关系研究，开发新药。  

【主要论著】

•  近5年主要论文：
  1. Design, synthesis and antibacterial activity of novel actinonin derivatives containing benzimidazole heterocycles， Datong Zhang, Zongheng Wang, Weiren Xu, Fanggang Sun, Lida Tang, Jianwu Wang,，  European Journal of Medicinal Chemistry，44 (2009) 2202- 2210

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  2.  A NOVEL AND EFFICIENT APPROACH TO PYRAZOLO[1,5-a]- PYRIDINE DERIVATIVES VIA ONE-POT TANDEM REACTION,  Yan-Qing Ge, Jiong Jia, Yan Li, Ling Yin, and Jianwu Wang* HETEROCYCLES, Vol 78, Issue 1, 2009, pp.197-206

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  3.  A FACILE APPROACH TO INDOLIZINES VIA TANDEM REACTION, Yan-Qing Ge, Jiong Jia, He Yang, Gui-Long Zhao, Fu-Xu Zhan, and Jianwu Wang*，HETEROCYCLES, Vol. 78, No. 3, 2009, pp. 725 - 736.

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  4.  Polyphosphoric Acid-Mediated, One-Pot, Novel Reactions to Build Polymethoxyarylnaphthalene Lignans，Guilong Zhao a; Fuxu Zhan b; Zhifeng Wang c; Weiren Xu a; Yuli Wang a; Wei Liu a; Lida Tang d;Jianwu Wang b，Synthetic Communications, 1, 40: 351–360, 2010

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  5.  FACILE SYNTHESIS OF IMIDAZO[1,2-a]PYRIDINES VIA TANDEM REACTION，Jiong Jia,1,2 Yan-Qing Ge,2 Xu-Tang Tao,1*and Jian-Wu Wang2*，HETEROCYCLES, Vol. 81, No. 1, 2010, pp. 185 - 194.

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  6.  Synthesis and antimicrobial activities of novel peptide deformylase inhibitors ，Ling Yin,a Wei-Ren Xu,b Zhi-Guo Wang,c Da-Tong Zhang,a Jiong Jia,a Yan-Qing Ge,aYan Li,a and Jian-Wu Wang a*，ARKIVOC 2010 (ix) 196-205

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  7. Synthesis and Preliminary Antibacterial Evaluation of 2-Butyl Succinate-based Hydroxamate Derivatives Containing Isoxazole Rings,Datong Zhang1,2, Jiong Jia1, Lijuan Meng1, Weiren Xu3, Lida Tang3, and Jianwu Wang1，Arch Pharm Res， 2010，0Vol 33, No 6, 831-842.
  

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• 8. Design,Synthesis and in vivo hypoglycemic activity of tetrazole-bearing N-glycosides as SGLT2 inhibitors, Y L Gao, G L Zhao, W Liu, H Shao, Y L Wang, W R Xu, L D Tang & J W Wang*, Indian Journal of Chemistry, Vol. 49b, November 2010,pp. 1499-1508.

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  9. The synthesis, characterization and optical properties of novel pyrido[1,2-a]benzimidazole derivatives，Yan Qing Ge a,c,1, Jiong Jia a,b,1, He Yang a, Xu Tang Tao b,*, Jian Wu Wang a,* Dyes and Pigments， 88 (2011)， 344-349

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  10. Synthesis and optical properties of novel pyrido[1,2-a]benzimidazole-containing 1,3,4-oxadiazole derivatives，He Yang, Yan-Qing Ge, Jiong Jia, Jian-Wu Wang* Journal of Luminescence，131(2011) 749-755

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  11.  Synthesis, X-ray crystal structure and optical properties of novel 2,5-diaryl-1,3,4-oxadiazole derivatives containing substituted pyrazolo[1,5-a]pyridine units，He Yang, Jinglin Mu, Xia Chen, Lei Feng, Jiong Jia*, Jianwu Wang* Dyes and Pigments，Dyes and PigmentsVolume 91, Issue 3, December 2011, Pages 446-45

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  12.  Design, synthesis and antibacterial activity of novel N-formylhydroxylamine derivatives as PDF inhibitors,L Yina, J Jiaa, G L Zhaob, W R Xub, L D Tangb ＆ J W Wang*a，Indian Journal of chemistry,2011,50B may, pp695-703

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  13.  Exquisite Synthesis of a Designed PAR-1 Antagonist, Hua-Ming Miaoa)b), Gui-Long Zhao*b), Lin-Shan Zhangc), Hua Shaob), and Jian-Wu Wang*a) Helvetica Chimica Acta – Vol. 94 (2011) pp 1981-1993

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  14.  Design and Synthesis of Novel Pyrazole-based Lp-PLA2 Inhibitors Wang, Yia(王毅) Xu, Weirenb(徐为人) Shao, Huab(邵华) Xie, Yafeia(谢亚非) Wang, Jianwu*,a(王建武) Chin. J. Chem. 2011, 29, 2039—2048

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  15.  The synthesis, characterization and opticalproperties of novel 1,3,4-oxadiazole containing
  imidazo[1,5-a]pyridinederivatives， Yan Qing Ge a, BenQian Hao a, GuiYun Duan a,, JianWuWang b, Journal of Luminescence 131 (2011) 1070–1076

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  16．  Design, synthesis and in vivo anti-hyperglycemic activity of gem-dimethyl-bearing C-glucosides as SGLT2 inhibitors.   Zhao, Wen Jing; Shi, Yong Heng; Zhao, Gui Long; Wang, Yu Li; Shao, Hua; Li, Da Tang; Wang, Jian Wu.  Chinese Chemical Letters  (2011),  22(10),  1215-1218.   

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  17．  Synthesis and crystal structure ofethyl1-(2-bromoethyl)-3-(4-methoxyphenyl)-1H-pyrazole-5-carboxylate.   Wang, Yi; Shao, Hua; Xu, Wei-Ren; Wang, Jian-Wu.   Chinese Journal of Structural Chemistry  (2012),  31(1),  110-114.   

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  18.  Synthesis, X-ray crystal structure and opticalproperties of novel 2-aryl-3-ethoxycarbonyl-4-
  phenylpyrido[1,2-a]benzimidazoles,  Xia Chen,a He Yang,a Yanqing Ge,c Lei Feng,a Jiong Jiaa,b* andJianwu Wanga* Luminescence (2012), 27(5), 382-389   

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  19.  新型咖啡酸五环三萜酯的合成与保肝活性，贾炯, 孙学华, 邵腾飞, 金树根, 高月求, 王建武，有机化学 2012, 32 (04), pp 760-764

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  20.  From Cyclopropenes to Tetrasubstituted Furans: Tandem Isomerization/Alkenylation Sequence with Cu/Pd Relay Catalysis，Chuanling Song, Lin Ju, Mingchao Wang, Pengcheng Liu, Yuanzhe Zhang, Jianwu Wang,* and Zhenghu Xu*[a]， Chem. Eur. J. 2013, 19, 3584 – 3589 

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  21.  A NEW METHOD FOR THE SYNTHESIS OF [1,2,4]TRIAZOLO[1,5-a]-PYRIDINE DERIVATIVES，Wei-Ming Zhao,a Yan-Qing Ge,b* Wei-Ren Xu,c Gui-Long Zhao,c Jiong Jia,a and Jian-Wu Wanga* HETEROCYCLES, Vol. 87, No. 4, 2013, pp. 869-876. 

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  22.  SYNTHESIS OF NITROGEN BRIDGEHEAD HETEROCYCLES WITH PHOSPHONATES VIA A NOVEL TANDEM PROCESS，Ya-Fei Xie,a Yan-Qing Ge,a,b Lei Feng,a Hua-Qiang Xu,a Song Meng,a Gui-Long Zhao,c Wei-Ren Xu,c Jiong Jia,a* and Jian-Wu Wanga* HETEROCYCLES, Vol. 87, No. 4, 2013, pp.815-826. 

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  23. FACILE SYNTHESIS OF PYRIDO[1,2-a]BENZIMIDAZOLE DERIVATIVES VIA NOVEL TANDEM REACTION INVOLVING HORNER-EMMONS REACTION，Wen-Jing Zhao,a Ya-Fei Xie,a Yan-Qing Ge,b* Wei-Ren Xu,c Gui-Long Zhao,c and Jian-Wu Wanga*HETEROCYCLES, Vol. 87, No. 5, 2013, pp.1121-1126.  

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  24. Design, synthesis and biological activity of cyclohexane-bearing C-glucoside derivatives as SGLT2 inhibitors, Zhang, Shuo; Wang, Yu-Li; Wei, Qun-Chao; Xu, Wei-Ren; Tang, Li-Da; Zhao, Gui-Long; Wang, Jian-Wu,  Chinese Chemical Letters (2013), 24(5), 429-432.  

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  25．Dimerization of cyclopropenes to bifurans using tandem metal relay catalysis† Chuanling Song, Di Sun, Xianglong Peng, Jing Bai, Rongyi Zhang, Shengzhen Hou, Jianwu Wang and Zhenghu Xu*  Chem. Commun., 2013, 49, 9167—9169

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  26．Modular synthesis of all-substituted furans through oxidative carbonylation of cyclopropenes with tandem metal relay catalysis† Chuanling Song, Shuli Dong, Lei Feng, Xianglong Peng, Mingchao Wang,Jianwu Wang and Zhenghu Xu* Org. Biomol. Chem., 2013, 11, 6258–6262

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  27. Effect of the Substitution Pattern on the Intramolecular Charge-Transfer Emissions in Organoboron-Based Biphenyls, Diphenylacetylenes, and Stilbenes, Yi-Qiao Yan, Yan-Bang Li, Jian-Wu Wang,* and Cui-Hua Zhao*[a] Chem. Asian J. 2013, 8, 3164 – 3176

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  28. Discovery of 6-Deoxydapagliflozin as a Highly Potent Sodium-dependent Glucose Cotransporter 2 (SGLT2) Inhibitor for the Treatment of Type 2Diabetes,Lingyu Zhang1,2, Yuli Wang2, Huaqiang Xu1,2, Yongheng Shi2,3, Bingni Liu2, Qunchao Wei2,Weiren Xu2,3, Lida Tang2,3, Jianwu Wang1* and Guilong Zhao2*Medicinal Chemistry, 2014, 10, 304-317

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  29.The synthesis, characterization and optical properties of novel 5-(3-aryl-1H-pyrazol-5-yl)-2-(3-butyl-1-chloroimidazo[1,5-a] pyridin-7-yl)-1,3,4-oxadiazole ，Yan Qing Ge a,b, Jiong Jia a, Teng Wanga, Hong Wei Sun c, Gui Yun Duan b, Jian Wu Wang a,⇑Spectrochimica Acta Part A: ,Molecular and Biomolecular Spectroscopy 123 (2014) 336–341

• 30.Highly emissive dimesitylboryl-substituted 2,1,3-benzothiadiazole derivatives: photophysical properties and efficient fluorescent sensor for fluoride anions，Bin Wang, Hong Pan, Jiong Jia, Yan-Qing Ge, Wen-Qing Cai, Jian-Wu Wang *,Cui-Hua Zhao * Tetrahedron 70 (2014) 5488-5493
   

【科研项目】

•  1.国家重大基础研究973前期项目1个; PDF柔性模型及其抑制剂先导化合物的研究(2003CCA027).50万元;
   2.山东省科技计划专项2个; a.新型抗生素-扑洛利福乐克星的合 成   2001 ,b.PDF柔性模型及其抑制剂先导化合物的 研究  (032090104),10万元;
   3.山东省自然基金项目:“丙型肝炎病毒NS3/NS4A酶抑制剂的设计、合成及筛选”（Z2004C06）, 7万元;
   4.山东省自然基金项目: 氮桥头芳性氮杂五环并吡啶衍生物的  合成与药物研究(Y2008B40)  5万元；
   5.山东省科学技术发展计划项目：新型肽脱甲酰基酶抑制剂类抗生素的研究2009GG20002027  8万元；
   6.与科研院所合作项目6个; 60万元;
   7.与企业合作项目2个。20万元.
  

【科研成果】

• 科研成果：




•                    发表科研论文160多篇；




•                    承担项目１7个（国家级２个，省部级15个）；一项产品获部级奖。




•                    发明专利15个;




•                    医药及其医药中间体开发，十多个项目已应用于企业生产。

【联合培养情况】

【拟招收研究生情况】

• 招收研究生情况:
      硕士研究生培养    :1997-2014： 共34人,毕业30人;
      博士研究生培养:    2003-2014： 共20人,毕业15人;
   
      每年拟招收硕士生1-2人、博士研究生1-2人;
   
      本人培养的研究生适合从事工作领域:
      研究型: 进行有机合成及药物合成研究;
      教学型: 进行有机化学及药物化学教学;
      开发型: 进行有机化合物合成及药物中间体合成开发;